KEGG   Homo sapiens (human): 27005
Entry
27005             CDS       T01001                                 
Symbol
USP21, USP16, USP23
Name
(RefSeq) ubiquitin specific peptidase 21
  KO
K21634  ubiquitin carboxyl-terminal hydrolase 21 [EC:3.4.19.12]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04217  Necroptosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    27005 (USP21)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    27005 (USP21)
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    27005 (USP21)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.19  Omega peptidases
    3.4.19.12  ubiquitinyl hydrolase 1
     27005 (USP21)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C19: ubiquitin-specific protease family
   27005 (USP21)
Ubiquitin system [BR:hsa04121]
 Deubiquitinating enzyme (DUB)
  Ubiquitin-specific proteases (UBPs)
   UBP/USP
    27005 (USP21)
SSDB
Motif
Pfam: UCH UCH_1
Other DBs
NCBI-GeneID: 27005
NCBI-ProteinID: NP_001014443
OMIM: 604729
HGNC: 12620
Ensembl: ENSG00000143258
UniProt: Q9UK80
Structure
Position
1:161159500..161165723
AA seq 565 aa
MPQASEHRLGRTREPPVNIQPRVGSKLPFAPRARSKERRNPASGPNPMLRPLPPRPGLPD
ERLKKLELGRGRTSGPRPRGPLRADHGVPLPGSPPPTVALPLPSRTNLARSKSVSSGDLR
PMGIALGGHRGTGELGAALSRLALRPEPPTLRRSTSLRRLGGFPGPPTLFSIRTEPPASH
GSFHMISARSSEPFYSDDKMAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFC
LRRDFRQEVPGGGRAQELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQ
DAQEFLKLLMERLHLEINRRGRRAPPILANGPVPSPPRRGGALLEEPELSDDDRANLMWK
RYLEREDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCF
NLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGV
DFPLQRLSLGDFASDKAGSPVYQLYALCNHSGSVHYGHYTALCRCQTGWHVYNDSRVSPV
SENQVASSEGYVLFYQLMQEPPRCL
NT seq 1698 nt   +upstreamnt  +downstreamnt
atgccccaggcctctgagcaccgcctgggccgtacccgagagccacctgttaatatccag
ccccgagtgggatccaagctaccatttgcccccagggcccgcagcaaggagcgcagaaac
ccagcctctgggccaaaccccatgttacgacctctgcctccccggccaggtctgcctgat
gaacggctcaagaaactggagctgggacggggacggacctcaggccctcgtcccagaggc
ccccttcgagcagatcatggggttcccctgcctggctcaccacccccaacagtggctttg
cctctcccatctcggaccaacttagcccgttccaagtctgtgagcagtggggacttgcgt
ccaatggggattgccttgggagggcaccgtggcaccggagagcttggggctgcactgagc
cgcttggccctccggcctgagccacccactttgagacgtagcacttctctccgccgccta
gggggctttcctggaccccctaccctgttcagcatacggacagagccccctgcttcccat
ggctccttccacatgatatccgcccggtcctctgagcctttctactctgatgacaagatg
gctcatcacacactccttctgggctctggtcatgttggccttcgaaacctgggaaacacg
tgcttcctgaatgctgtgctgcagtgtctgagcagcactcgacctcttcgggacttctgt
ctgagaagggacttccggcaagaggtgcctggaggaggccgagcccaagagctcactgaa
gcctttgcagatgtgattggtgccctctggcaccctgactcctgcgaagctgtgaatcct
actcgattccgagctgtcttccagaaatatgttccctccttctctggatacagccagcag
gatgcccaagagttcctgaagctcctcatggagcggctacaccttgaaatcaaccgccga
ggccgccgggctccaccgatacttgccaatggtccagttccctctccaccccgccgagga
ggggctctgctagaagaacctgagttaagtgatgatgaccgagccaacctaatgtggaaa
cgttacctggagcgagaggacagcaagattgtggacctgtttgtgggccagttgaaaagt
tgtctcaagtgccaggcctgtgggtatcgctccacgaccttcgaggttttttgtgacctg
tccctgcccatccccaagaaaggatttgctgggggcaaggtgtctctgcgggattgtttc
aaccttttcactaaggaagaagagctagagtcggagaatgccccagtgtgtgaccgatgt
cggcagaaaactcgaagtaccaaaaagttgacagtacaaagattccctcgaatcctcgtg
ctccatctgaatcgattttctgcctcccgaggctccatcaaaaaaagttcagtaggtgta
gactttccactgcagcgactgagcctaggggactttgccagtgacaaagccggaagtcct
gtataccagctgtatgccctttgcaaccactcaggcagcgtccactatggccactacaca
gccctgtgccggtgccagactggttggcatgtctacaatgactctcgtgtctcccctgtc
agtgaaaaccaggtggcatccagcgagggctacgtgctgttctaccaactgatgcaggag
ccaccccggtgcctgtga

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (23)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (21)   
DNA sequence (56)   
   RefSeq(nuc) (22)   
   GenBank (17)   
   EMBL (17)   
3D Structure (3)   
   PDB (3)   
Protein domain (2)   
   Pfam (2)   
All databases (106)   

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